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Barrett’s esophagus (Metaplasia)
Esophageal cancer frequently arises in patients with Barrett’s esophagus. Barrett’s esophagus is a change in the lining of the tissue of the esophagus that is thought to be caused by chronic GERD. Approximately 12% of people with chronic GERD are found to have Barrett’s esophagus. It is more common in older white men and is rare in Asians and African Americans. Patients with Barrett’s esophagus are advised to undergo endoscopy regularly to watch for any abnormal tissue in the esophagus that may precede cancerous changes. Treatment for Barrett's esophagus includes either ablation of the abnomral tissue or close observation to watch for signs of progression towards cancer. It is also very important to prevent continued irritation of the esophagus that may lead to the development of cancer. This includes chronic long term acid suppression, usually with proton pump inhibitors, or anti-reflux surgery. (Additional information)

Esophageal Cancer
Over the past decade the rate of esophageal cancer has risen at an alarming rate. The number of new cases of esophageal cancer has increased more than almost any other type of cancer.


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Esophageal cancer is still a relatively rare cancer.

Most of the increase in the rate of esophageal cancer has occurred in the rate of esophageal adenocarcinoma. This is the type of esophgeal cancer that is sometimes associated with GERD. A recent study suggested that the more frequent, more severe, and longer-lasting the symptoms of reflux, the greater the risk for esophageal cancer.
Some potential warning signs of esophageal cancer are:
  • Pain or difficulty swallowing
  • Feeling full after eating only a small amount
  • Frequent vomiting
  • Unexplained weight loss
  • Severe hoarseness or wheezing
  • Chest pain
  • Blood in your stool or black tarry stools
  • Vomiting blood

If you have severe GERD symptoms that do not respond to medical treatment or any of the “alarm signs” mentioned above, you should be evaluated by a physician.

Additional Information

Barrettsinfo.com


Mayo Clinic


 A very comprehensive site developed by experts using an unrestricted grant from the makers of Nexium.

Information about Esophageal cancer and Barrett's Esophagus.
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